Preparing a pre-metastatic niche in the bone marrow through the remote control of translation by tumour-derived non-coding RNAs
Two junior post-doctoral positions are open to work on an innovative joint research program between LyOS and CRCL in Lyon, France. The program aims to investigate the translational control mediated by tumour-derived non-coding RNAs on the nesting of disseminated tumour cells in the bone marrow. The successful applicants will study the functions of tumour-derived microRNAs/snoRNAs that are specifically associated with breast cancer bone metastasis and examine the role of their translationnally regulated mRNA targets involved in preparing the pre-metastatic niche. Overall, the objective of this program is to decipher the remotely controlled translational landscape that mediates bone metastasis formation in breast cancer.