Project
Microenvironment Metabolism-Adapted Vaccination for Enhanced Reactivation of Immunosurveillance in Advanced Prostate Cancer. The NuReP team (Nuclear Receptors & Pathophysiology) at iGReD – Université Clermont Auvergne/CNRS/Inserm is seeking a highly motivated postdoctoral researcher to join the INCa-funded MAVERIC project.
Research Project
Advanced prostate cancer remains largely resistant to immunotherapy, partly due to an immunosuppressive tumor microenvironment. MAVERIC aims to determine how metabolic reprogramming of dendritic cells can restore antitumor immunosurveillance. The project focuses on Liver X Receptors (LXRs), cholesterol-sensing nuclear receptors linking metabolism and immunity. Using an innovative orthotopic metastatic prostate cancer model, we will develop an in situ vaccination strategy combining tumor antigens, TLR ligands and novel LXRα-selective ligands. Treatment-induced remodeling of the tumor microenvironment will be investigated using spectral cytometry, scRNA-seq and spatial transcriptomics, with the goal of providing preclinical proof-of-concept for a new immunometabolic therapeutic strategy.
Voir l’annonce >> Postdoctoral Position
